It's quite similar to how MGM ended their partnership with Disney.
I know it's such an iconic building, but they had to move all their shows that were still being produced there as of 2005 to their new Sunset Boulevard TV studio in Hollywood, Nickelodeon on Sunset. They had very few TV shows being filmed in Florida. The last few shows to be filmed there were "SPLAT!" and "My Family's Got Guts."
The Blue Man Group now uses one of their soundstages to perform their shows. That entire area was re-zoned from Production Central to Universal CityWalk.